Hepatic adenoma mimicking a Leydig-sertoli cell tumor metastasis

Thomas Rossor, Alberto Quaglia, Stergios Zacharoulis, Sandra Strautnieks, Mark Davenport, Nedim Hadžić


Objective – A description of the co-occurence of two rare paediatric neoplasias, and a discussion of the possible pathogenic processes and potential role of a tumour disposition syndrome.

Case report – We describe a 14 year old girl presenting with an abdominal mass which was found on resection to be a Leydig-Sertoli cell tumour. This was associated with a hepatic lesion suspected of a metastasis. Due to persistence despite chemotherapy the liver lesion was resected and confirmed to be a hepatocellular adenoma, providing the first reported cooccurrence of these rare neoplasms.

Conclusion – Hormonal activity of a Sertoli-Leydig cell tumour may predispose to hepatic adenoma, or the coincidence of these two tumours may be accounted for by a tumour predisposition syndrome. When investigating liver lesions the potential for an adenoma to mimic a metastasis should be considered.


Adenoma; Liver cell; Sertoli Leydig cell tumor; Hyperthyroidism

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DOI: https://doi.org/10.5457/p2005-114.76


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