Hepatic adenoma mimicking a Leydig-sertoli cell tumor metastasis

Abstract

Objective – A description of the co-occurence of two rare paediatric neoplasias, and a discussion of the possible pathogenic processes and potential role of a tumour disposition syndrome.

Case report – We describe a 14 year old girl presenting with an abdominal mass which was found on resection to be a Leydig-Sertoli cell tumour. This was associated with a hepatic lesion suspected of a metastasis. Due to persistence despite chemotherapy the liver lesion was resected and confirmed to be a hepatocellular adenoma, providing the first reported cooccurrence of these rare neoplasms.

Conclusion – Hormonal activity of a Sertoli-Leydig cell tumour may predispose to hepatic adenoma, or the coincidence of these two tumours may be accounted for by a tumour predisposition syndrome. When investigating liver lesions the potential for an adenoma to mimic a metastasis should be considered.