Severe virilization in adolescent girl with Sertoli-Leydig cell tumor – case report and review of the literature

Nevena Krnic, Natasa Rojnic Putarek, Katja Dumic Kubat, Mihajlo Strelec, Anita Spehar Uroic, Marija Macan, Lana Skrgatic, Vesna Kusec


Objective – The aim was to report a case of a 17-year-old girl with marked virilization and secondary amenorrhea due to androgen producing Sertoli-Leydig cell tumor (SLCT). We also provided a brief review of the literature with insight into clinical picture, pathological features and treatment of patients with this rare tumor.

Case report − We present a 17-year-old girl with SLCT, who developed clinical symptoms of severe virilization. The tumor secreted testosterone and alpha fetoprotein (AFP). The imaging revealed tumor of the right ovary which histologically corresponded to intermediate-grade SLCT with low mitotic rate. Furthermore, it was stage IA according to International Federation of Gynecology and Obstetrics. Laparoscopic right salpingo-oophorectomy was preformed, resulting in regression of virilization symptoms and normalization of serum testosterone and AFP levels.

Conclusion − Due to rarity of SLCT in children and adolescents, gathering information from available case reports is necessary to establish guidelines regarding optimal management, including type of surgery and adjuvant chemotherapy. New knowledge regarding related diseases in SLCT survivors emphasize the need for long-term follow up of these patients.


Sertoli-Leydig cell tumor; Sex cord-stromal tumor; Virilization; Alpha fetoprotein

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